The purpose of the current study was to develop a novel taste masked mouth dissolving tablets of Tramadol HCl. Tramadol HCl is an opioid analgesic used for the treatment of moderate to severe pain. Mouth dissolving tablets offer substantial advantages but its crucial aspect is to mask the bitter taste and to minimize the disintegration time. In the present investigation, the bitter taste of Tramadol HCl was masked by three different approaches- solid dispersion, inclusion complex and ion exchange resin. The mouth dissolving tablets were prepared by sublimation technique using camphor as subliming agent. The result revealed faster release profile of Tramadol HCl using sublimation technique. Out of the three approaches utilized, ion exchange resin (Kyron T314) exhibited highest taste masking of Tramadol HCl. Hence it can be concluded that ion exchange resin with sublimation technique demonstrated potentials for taste masking, rapid absorption, improved bioavailability, effective therapy and patient compliance.
Loading....